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Indole-3-carbinol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway.

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Title: Indole-3-carbinol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway.
Authors: Zhu F; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. zhufengyu@ahmu.edu.cn.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. zhufengyu@ahmu.edu.cn., Li F; Department of Emergency, Linquan County People's Hospital, Linquan, 236400, China.; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., Zhang R; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., He Z; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., Li J; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., Zhang N; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., Chen H; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., Chen J; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China., Cheng L; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. chenglinghui71@163.com.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. chenglinghui71@163.com., Zhong F; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. zhongfei@ahmu.edu.cn.; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China. zhongfei@ahmu.edu.cn.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. zhongfei@ahmu.edu.cn.; Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. zhongfei@ahmu.edu.cn.
Source: Journal of ovarian research [J Ovarian Res] 2026 Feb 03; Vol. 19 (1). Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Indole-3-carbinol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+F%22">Zhu F</searchLink>; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. zhufengyu@ahmu.edu.cn.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. zhufengyu@ahmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Department of Emergency, Linquan County People's Hospital, Linquan, 236400, China.; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Cheng+L%22">Cheng L</searchLink>; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. chenglinghui71@163.com.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. chenglinghui71@163.com.<br /><searchLink fieldCode="AU" term="%22Zhong+F%22">Zhong F</searchLink>; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Shushan District, Hefei, 230022, Anhui Province, China. zhongfei@ahmu.edu.cn.; Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China. zhongfei@ahmu.edu.cn.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, (Anhui Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. zhongfei@ahmu.edu.cn.; Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. zhongfei@ahmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101474849%22">Journal of ovarian research</searchLink> [J Ovarian Res] 2026 Feb 03; Vol. 19 (1). <i>Date of Electronic Publication: </i>2026 Feb 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101474849 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-2215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217572215%22">17572215 </searchLink><i>NLM ISO Abbreviation: </i>J Ovarian Res <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41634829
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1186/s13048-026-01994-2
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      – Code: eng
        Text: English
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      – TitleFull: Indole-3-carbinol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway.
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            – D: 03
              M: 02
              Text: 2026 Feb 03
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              Y: 2026
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