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A computational framework for sensitive tumor detection and accurate subtyping using shallow cell-free DNA methylome sequencing.

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Title: A computational framework for sensitive tumor detection and accurate subtyping using shallow cell-free DNA methylome sequencing.
Authors: Paoli M; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Galardi F; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Nardone A; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Biagioni C; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Romagnoli D; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Di Donato S; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Franceschini GM; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Livraghi L; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Pestrin M; Medical Oncology Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Gorizia, Italy., Sanna G; Medical Oncology, Ospedale Civile SS Annunziata, Sassari, Italy., Risi E; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Migliaccio I; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Moretti E; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Malorni L; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Biganzoli L; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy., Demichelis F; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Benelli M; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy. matteo.benelli@unifi.it.; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy. matteo.benelli@unifi.it.
Source: Genome medicine [Genome Med] 2026 Feb 03; Vol. 18 (1). Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A computational framework for sensitive tumor detection and accurate subtyping using shallow cell-free DNA methylome sequencing.
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  Data: <searchLink fieldCode="AU" term="%22Paoli+M%22">Paoli M</searchLink>; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Galardi+F%22">Galardi F</searchLink>; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Nardone+A%22">Nardone A</searchLink>; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Biagioni+C%22">Biagioni C</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Romagnoli+D%22">Romagnoli D</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Donato+S%22">Di Donato S</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Franceschini+GM%22">Franceschini GM</searchLink>; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Livraghi+L%22">Livraghi L</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Pestrin+M%22">Pestrin M</searchLink>; Medical Oncology Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Gorizia, Italy.<br /><searchLink fieldCode="AU" term="%22Sanna+G%22">Sanna G</searchLink>; Medical Oncology, Ospedale Civile SS Annunziata, Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Risi+E%22">Risi E</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Migliaccio+I%22">Migliaccio I</searchLink>; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Moretti+E%22">Moretti E</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Malorni+L%22">Malorni L</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.; Translational Research Unit, Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Biganzoli+L%22">Biganzoli L</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Demichelis+F%22">Demichelis F</searchLink>; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Benelli+M%22">Benelli M</searchLink>; Department of Medical Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy. matteo.benelli@unifi.it.; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy. matteo.benelli@unifi.it.
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  Data: <searchLink fieldCode="JN" term="%22101475844%22">Genome medicine</searchLink> [Genome Med] 2026 Feb 03; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Feb 03.
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