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Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling.

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Title: Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling.
Authors: Dubinsky S; Department of Critical Care, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. sam.dubinsky@nshealth.ca., McIntyre M; Sinai Health-University Health Network Antimicrobial Stewardship Program, Mount Sinai Hospital, Toronto, ON, Canada.; University of Toronto Leslie Dan Faculty of Pharmacy, Toronto, ON, Canada., Kim MS; School of Pharmacy, University of Waterloo, Kitchener, ON, Canada., Hawryluk L; Critical Care Medicine, University of Toronto, Toronto, ON, Canada.; Medical Surgical/Neuroscience Intensive Care Unit, Toronto Western Hospital, Toronto, ON, Canada., Edginton A; School of Pharmacy, University of Waterloo, Kitchener, ON, Canada.
Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2026 Mar; Vol. 51 (2), pp. 193-204. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2107-0180 (Electronic) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Dubinsky+S%22">Dubinsky S</searchLink>; Department of Critical Care, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. sam.dubinsky@nshealth.ca.<br /><searchLink fieldCode="AU" term="%22McIntyre+M%22">McIntyre M</searchLink>; Sinai Health-University Health Network Antimicrobial Stewardship Program, Mount Sinai Hospital, Toronto, ON, Canada.; University of Toronto Leslie Dan Faculty of Pharmacy, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+MS%22">Kim MS</searchLink>; School of Pharmacy, University of Waterloo, Kitchener, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hawryluk+L%22">Hawryluk L</searchLink>; Critical Care Medicine, University of Toronto, Toronto, ON, Canada.; Medical Surgical/Neuroscience Intensive Care Unit, Toronto Western Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Edginton+A%22">Edginton A</searchLink>; School of Pharmacy, University of Waterloo, Kitchener, ON, Canada.
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        Value: 10.1007/s13318-025-00981-0
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        Text: English
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              Text: 2026 Mar
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