View in EDS

Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2.

Saved in:
Bibliographic Details
Title: Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2.
Authors: Haymer DH; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Duncan RA; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Rodriguez AL; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Han A; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Lindsay RJ; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Center for AI in Protein Dynamics, Vanderbilt University, Nashville, Tennessee 37232, United States., Wijesiri NK; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Center for AI in Protein Dynamics, Vanderbilt University, Nashville, Tennessee 37232, United States., Thompson Gray A; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Krishnan S; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Qi A; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Brown BP; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Center for AI in Protein Dynamics, Vanderbilt University, Nashville, Tennessee 37232, United States., Boutaud O; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States., Engers DW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Jones CK; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States., Niswender CM; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States., Lindsley CW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States., Bender AM; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 4187-4207. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41642702
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Haymer+DH%22">Haymer DH</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Duncan+RA%22">Duncan RA</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Rodriguez+AL%22">Rodriguez AL</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Han+A%22">Han A</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Lindsay+RJ%22">Lindsay RJ</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Center for AI in Protein Dynamics, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Wijesiri+NK%22">Wijesiri NK</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Center for AI in Protein Dynamics, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Thompson+Gray+A%22">Thompson Gray A</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Krishnan+S%22">Krishnan S</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Qi+A%22">Qi A</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Brown+BP%22">Brown BP</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Center for AI in Protein Dynamics, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Boutaud+O%22">Boutaud O</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Engers+DW%22">Engers DW</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Jones+CK%22">Jones CK</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Niswender+CM%22">Niswender CM</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Lindsley+CW%22">Lindsley CW</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute for Therapeutic Advances, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Bender+AM%22">Bender AM</searchLink>; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 4187-4207. <i>Date of Electronic Publication: </i>2026 Feb 05.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE; In Process
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41642702
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.5c02796
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 4187
    Titles:
      – TitleFull: Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Haymer DH
      – PersonEntity:
          Name:
            NameFull: Duncan RA
      – PersonEntity:
          Name:
            NameFull: Rodriguez AL
      – PersonEntity:
          Name:
            NameFull: Han A
      – PersonEntity:
          Name:
            NameFull: Lindsay RJ
      – PersonEntity:
          Name:
            NameFull: Wijesiri NK
      – PersonEntity:
          Name:
            NameFull: Thompson Gray A
      – PersonEntity:
          Name:
            NameFull: Krishnan S
      – PersonEntity:
          Name:
            NameFull: Qi A
      – PersonEntity:
          Name:
            NameFull: Brown BP
      – PersonEntity:
          Name:
            NameFull: Boutaud O
      – PersonEntity:
          Name:
            NameFull: Engers DW
      – PersonEntity:
          Name:
            NameFull: Jones CK
      – PersonEntity:
          Name:
            NameFull: Niswender CM
      – PersonEntity:
          Name:
            NameFull: Lindsley CW
      – PersonEntity:
          Name:
            NameFull: Bender AM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 02
              Text: 2026 Feb 26
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 69
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1