Design, catalyst-free synthesis, DFT study and anticancer assessment of new 2,9-disubstituted purine-6-carboxamides.

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Title: Design, catalyst-free synthesis, DFT study and anticancer assessment of new 2,9-disubstituted purine-6-carboxamides.
Authors: Chatterjee J; Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda 151401, India., Bhujbal SM; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160062, India., Joshi G; Institute of Cancer Therapeutics, School of Pharmacy & Medical Sciences, Faculty of Life Sciences, University of Bradford, BD71DP, United Kingdom; Department of Pharmaceutical Science, Hemvati Nandan Bahuguna Garhwal (A Central) University, Srinagar 246174, Dist. Garhwal, Uttarakhand, India., Mishra UK; Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India., Sharon A; Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India., Muskan; Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda 151401, India., Singh S; Centre for Immunobiology and Immunotherapy, BRIC-Translational Health Science and Technology Institute, (An autonomous institute of the Dept of Biotechnology, Govt of India) Faridabad (Delhi NCR), Haryana 121001, India., Wahajuddin M; Institute of Cancer Therapeutics, School of Pharmacy & Medical Sciences, Faculty of Life Sciences, University of Bradford, BD71DP, United Kingdom., Bharatam PV; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160062, India., Dalal R; Centre for Immunobiology and Immunotherapy, BRIC-Translational Health Science and Technology Institute, (An autonomous institute of the Dept of Biotechnology, Govt of India) Faridabad (Delhi NCR), Haryana 121001, India., Kumar R; Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda 151401, India. Electronic address: raj.khunger@cup.edu.in.
Source: Bioorganic chemistry [Bioorg Chem] 2026 May; Vol. 172, pp. 109529. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1090-2120
DOI:10.1016/j.bioorg.2026.109529