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Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma.

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Title: Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma.
Authors: Chen YC; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Gao XL; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zeng G; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zhang KK; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Yuan C; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Cheng CH; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Wan JY; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zhou HQ; Department of Critical Care, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China., Lan ZX; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zheng DK; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., You QH; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Sun J; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. sunjian@smu.edu.cn.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China. sunjian@smu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1629-1642. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: Asiatic acid promotes CD8<superscript>+</superscript> T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Gao+XL%22">Gao XL</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zeng+G%22">Zeng G</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zhang+KK%22">Zhang KK</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Yuan+C%22">Yuan C</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Cheng+CH%22">Cheng CH</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Wan+JY%22">Wan JY</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zhou+HQ%22">Zhou HQ</searchLink>; Department of Critical Care, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.<br /><searchLink fieldCode="AU" term="%22Lan+ZX%22">Lan ZX</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zheng+DK%22">Zheng DK</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22You+QH%22">You QH</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. sunjian@smu.edu.cn.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China. sunjian@smu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1629-1642. <i>Date of Electronic Publication: </i>2026 Feb 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-025-01739-9
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      – TitleFull: Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma.
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