Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma.
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| Title: | Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma. |
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| Authors: | Chen YC; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Gao XL; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zeng G; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zhang KK; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Yuan C; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Cheng CH; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Wan JY; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zhou HQ; Department of Critical Care, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China., Lan ZX; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Zheng DK; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., You QH; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China., Sun J; Key Laboratory of Infectious Diseases Research in South China, Ministry of Education; Guangdong Provincial Research Center for Liver Fibrosis Engineering and Technology; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. sunjian@smu.edu.cn.; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases; Guangdong Provincial Clinical Research Center for Viral Hepatitis; Guangdong Institute of Hepatology, Guangzhou, 510515, China. sunjian@smu.edu.cn. |
| Source: | Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1629-1642. Date of Electronic Publication: 2026 Feb 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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