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PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade.

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Title: PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade.
Authors: Yashar WM; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; These authors contributed equally to this work. For CV and publication listings, both authors may designate themselves as the first author., Pacentine IV; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; These authors contributed equally to this work. For CV and publication listings, both authors may designate themselves as the first author., Taherinasab A; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA., Nguyen T; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA., Worme S; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA., Tsuchiya M; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA., Lusardi T; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Cancer Early Detection Advanced Research Center, Oregon Health & Science University; Portland, OR, 97239, USA., Hutchinson C; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA., Fillmore TL; Environmental and Molecular Sciences Division, Pacific Northwest National Laboratory, Richland WA., Posso C; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA., Gosline SJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA., Piehowski PD; Environmental and Molecular Sciences Division, Pacific Northwest National Laboratory, Richland WA., Yardimci GG; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Cancer Early Detection Advanced Research Center, Oregon Health & Science University; Portland, OR, 97239, USA., Adey AC; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA.; Environmental and Molecular Sciences Division, Pacific Northwest National Laboratory, Richland WA., Maxson JE; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Cell Developmental & Cancer Biology, Oregon Health & Science University; Portland, OR, 97239, USA., Braun TP; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 23. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade.
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  Data: <searchLink fieldCode="AU" term="%22Yashar+WM%22">Yashar WM</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; These authors contributed equally to this work. For CV and publication listings, both authors may designate themselves as the first author.<br /><searchLink fieldCode="AU" term="%22Pacentine+IV%22">Pacentine IV</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; These authors contributed equally to this work. For CV and publication listings, both authors may designate themselves as the first author.<br /><searchLink fieldCode="AU" term="%22Taherinasab+A%22">Taherinasab A</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Worme+S%22">Worme S</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Tsuchiya+M%22">Tsuchiya M</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Lusardi+T%22">Lusardi T</searchLink>; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Cancer Early Detection Advanced Research Center, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Hutchinson+C%22">Hutchinson C</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA.<br /><searchLink fieldCode="AU" term="%22Fillmore+TL%22">Fillmore TL</searchLink>; Environmental and Molecular Sciences Division, Pacific Northwest National Laboratory, Richland WA.<br /><searchLink fieldCode="AU" term="%22Posso+C%22">Posso C</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA.<br /><searchLink fieldCode="AU" term="%22Gosline+SJ%22">Gosline SJ</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA.<br /><searchLink fieldCode="AU" term="%22Piehowski+PD%22">Piehowski PD</searchLink>; Environmental and Molecular Sciences Division, Pacific Northwest National Laboratory, Richland WA.<br /><searchLink fieldCode="AU" term="%22Yardimci+GG%22">Yardimci GG</searchLink>; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Cancer Early Detection Advanced Research Center, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Adey+AC%22">Adey AC</searchLink>; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA.; Environmental and Molecular Sciences Division, Pacific Northwest National Laboratory, Richland WA.<br /><searchLink fieldCode="AU" term="%22Maxson+JE%22">Maxson JE</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Cell Developmental & Cancer Biology, Oregon Health & Science University; Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Braun+TP%22">Braun TP</searchLink>; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.; Knight Cancer Institute, Oregon Health & Science University; Portland, OR, 97239, USA.; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University; Portland, OR, 97239, USA.
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        Value: 10.64898/2026.01.20.700677
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        Text: English
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