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Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route.

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Title: Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route.
Authors: Johnston SC; Virology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Ginnetti AT; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Twenhafel NA; Pathology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Norris SLW; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Chen S; Merck and Co., Inc., Rahway, New Jersey, United States of America., Moore JL; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Boyce CW; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Frick OM; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Dyer DN; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Marsh DJ; Merck and Co., Inc., Rahway, New Jersey, United States of America., Stevens SC; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Knapp WF; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Berrier KL; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Wan H; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Adam GC; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Hartingh TJ; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Esham HL; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Fiallos JO; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Blue EL; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Sifford WB; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Latty JD; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Mills HL; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Alli NA; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Piper AE; Virology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Goodson AI; Research Program Office, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Meinig JM; Bacteriology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America., Olsen DB; Merck and Co., Inc., West Point, Pennsylvania, United States of America., Lieberman LA; Merck and Co., Inc., Cambridge, Massachusetts, United States of America., Panchal RG; Molecular Biology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.
Source: PloS one [PLoS One] 2026 Feb 06; Vol. 21 (2), pp. e0340118. Date of Electronic Publication: 2026 Feb 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
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  Data: Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route.
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Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Boyce+CW%22">Boyce CW</searchLink>; Merck and Co., Inc., West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Frick+OM%22">Frick OM</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Dyer+DN%22">Dyer DN</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Marsh+DJ%22">Marsh DJ</searchLink>; Merck and Co., Inc., Rahway, New Jersey, United States of America.<br /><searchLink fieldCode="AU" term="%22Stevens+SC%22">Stevens SC</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Knapp+WF%22">Knapp WF</searchLink>; Merck and Co., Inc., West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Berrier+KL%22">Berrier KL</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Wan+H%22">Wan H</searchLink>; Merck and Co., Inc., West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Adam+GC%22">Adam GC</searchLink>; Merck and Co., Inc., West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Hartingh+TJ%22">Hartingh TJ</searchLink>; Merck and Co., Inc., West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Esham+HL%22">Esham HL</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Fiallos+JO%22">Fiallos JO</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Blue+EL%22">Blue EL</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Sifford+WB%22">Sifford WB</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Latty+JD%22">Latty JD</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Mills+HL%22">Mills HL</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Alli+NA%22">Alli NA</searchLink>; Veterinary Medicine Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Piper+AE%22">Piper AE</searchLink>; Virology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Goodson+AI%22">Goodson AI</searchLink>; Research Program Office, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Meinig+JM%22">Meinig JM</searchLink>; Bacteriology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Olsen+DB%22">Olsen DB</searchLink>; Merck and Co., Inc., West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Lieberman+LA%22">Lieberman LA</searchLink>; Merck and Co., Inc., Cambridge, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Panchal+RG%22">Panchal RG</searchLink>; Molecular Biology Division, United States of America Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.
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