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Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.

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Title: Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.
Authors: Vignolo SM; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Roth DM; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Fraga MAA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Restorative Dentistry, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, SP, Brazil; Division of Oncological Sciences, School of Medicine, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Wu L; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Cosgrove JA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Athirasala A; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Oral Rehabilitation and Biosciences, School of Dentistry, OHSU, 2730 S. Moody Ave., Portland, OR 97201, USA., Lin ASP; Phil and Penny Knight Campus for Accelerating Scientific Impact, Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA., Guldberg RE; Phil and Penny Knight Campus for Accelerating Scientific Impact, Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA., Bertassoni LE; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Division of Oncological Sciences, School of Medicine, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Oral Rehabilitation and Biosciences, School of Dentistry, OHSU, 2730 S. Moody Ave., Portland, OR 97201, USA. Electronic address: bertasso@ohsu.edu.
Source: Acta biomaterialia [Acta Biomater] 2026 Feb 04. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-7568
DOI:10.1016/j.actbio.2026.02.003