Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.

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Title: Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.
Authors: Vignolo SM; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Roth DM; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Fraga MAA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Restorative Dentistry, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, SP, Brazil; Division of Oncological Sciences, School of Medicine, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Wu L; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Cosgrove JA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA., Athirasala A; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Oral Rehabilitation and Biosciences, School of Dentistry, OHSU, 2730 S. Moody Ave., Portland, OR 97201, USA., Lin ASP; Phil and Penny Knight Campus for Accelerating Scientific Impact, Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA., Guldberg RE; Phil and Penny Knight Campus for Accelerating Scientific Impact, Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA., Bertassoni LE; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Division of Oncological Sciences, School of Medicine, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Oral Rehabilitation and Biosciences, School of Dentistry, OHSU, 2730 S. Moody Ave., Portland, OR 97201, USA. Electronic address: bertasso@ohsu.edu.
Source: Acta biomaterialia [Acta Biomater] 2026 Feb 04. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Vignolo+SM%22">Vignolo SM</searchLink>; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Roth+DM%22">Roth DM</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Fraga+MAA%22">Fraga MAA</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Restorative Dentistry, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, SP, Brazil; Division of Oncological Sciences, School of Medicine, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Cosgrove+JA%22">Cosgrove JA</searchLink>; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Athirasala+A%22">Athirasala A</searchLink>; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Oral Rehabilitation and Biosciences, School of Dentistry, OHSU, 2730 S. Moody Ave., Portland, OR 97201, USA.<br /><searchLink fieldCode="AU" term="%22Lin+ASP%22">Lin ASP</searchLink>; Phil and Penny Knight Campus for Accelerating Scientific Impact, Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA.<br /><searchLink fieldCode="AU" term="%22Guldberg+RE%22">Guldberg RE</searchLink>; Phil and Penny Knight Campus for Accelerating Scientific Impact, Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA.<br /><searchLink fieldCode="AU" term="%22Bertassoni+LE%22">Bertassoni LE</searchLink>; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University (OHSU), 3303 S. Bond Ave., Portland, OR 97201, USA; Knight Cancer Precision Biofabrication Hub, Knight Cancer Institute (KCI), OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Cancer Early Detection Advanced Research Center (CEDAR), KCI, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Division of Oncological Sciences, School of Medicine, OHSU, 2720 S. Moody Ave., Portland, OR 97201, USA; Department of Oral Rehabilitation and Biosciences, School of Dentistry, OHSU, 2730 S. Moody Ave., Portland, OR 97201, USA. Electronic address: bertasso@ohsu.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101233144 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-7568 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217427061%22">17427061 </searchLink><i>NLM ISO Abbreviation: </i>Acta Biomater <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.actbio.2026.02.003
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        Text: English
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              Text: 2026 Feb 04
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