Radiotherapy enhances M1 macrophage immunogenic activity through IFNs induction and stimulation in TP53-wild type tumors.

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Title: Radiotherapy enhances M1 macrophage immunogenic activity through IFNs induction and stimulation in TP53-wild type tumors.
Authors: Cheng CC; Research Center of Radiation Medicine, Chang Gung University, Taoyuan, 333, Taiwan.; Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, 333, Taiwan., Yeh HZ; Division of Gastroenterology and Hepatology, Tungs' Taichung Metro Harbor Hospital, Taichung, 406, Taiwan., Sie ZL; Research Center of Radiation Medicine, Chang Gung University, Taoyuan, 333, Taiwan., Wang CL; Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, 333, Taiwan., Peng CL; Department of Isotope Application Research, National Atomic Research Institute, Taoyuan, 325, Taiwan., Ho AS; Division of Gastroenterology, Cheng Hsin General Hospital, Taipei, 112, Taiwan., Wang CI; Department of Biochemistry, School of Medicine, China Medical University, Taichung, 400, Taiwan. ciwang@mail.cmu.edu.tw., Chang CC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, 110, Taiwan. chunchao@tmu.edu.tw.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. chunchao@tmu.edu.tw.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 110, Taiwan. chunchao@tmu.edu.tw.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Feb 07; Vol. 75 (3), pp. 71. Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1432-0851
DOI:10.1007/s00262-026-04300-7