Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial.
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| Title: | Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial. |
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| Authors: | Colson AE; Community Resource Initiative, Boston, MA, USA; Cambridge Health Alliance, Cambridge, MA, USA., Mills AM; Men's Health Foundation, Los Angeles, CA, USA., Ramgopal MN; Midway Immunology and Research Center, Fort Pierce, FL, USA., Bettacchi C; HIV Center, North Texas Infectious Diseases Consultants, Dallas, TX, USA., Osiyemi OO; Triple O Research Institute, West Palm Beach, FL, USA., Hinestrosa F; Orlando Immunology Center, Orlando, FL, USA., Crofoot G; The Crofoot Research Center, Houston, TX, USA., Katner HP; Mercer University School of Medicine, Macon, GA, USA., Gatanaga H; AIDS Clinical Center, NCGM, Tokyo, Japan., Johnson M; Royal Free London NHS Foundation Trust, London, UK., Diamond TL; Merck & Co, Rahway, NJ, USA., Barninger E; Merck & Co, Rahway, NJ, USA., Eves K; Merck & Co, Rahway, NJ, USA., Su FH; Merck & Co, Rahway, NJ, USA., Xu Y; Merck & Co, Rahway, NJ, USA., Klopfer SO; Merck & Co, Rahway, NJ, USA., Stamm LM; Merck & Co, Rahway, NJ, USA., Fox MC; Merck & Co, Rahway, NJ, USA., Lahoulou R; Merck & Co, Rahway, NJ, USA. Electronic address: rima.lahoulou@merck.com. |
| Source: | Lancet (London, England) [Lancet] 2026 Feb 07; Vol. 407 (10528), pp. 611-621. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Equivalence Trial |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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