Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality.

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Title: Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality.
Authors: Fleischauer J; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., John-Neek P; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Ha TC; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Mansel F; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Kosanke M; Research Core Unit Genomics, Hannover Medical School, 30625, Hannover, Germany.; The Faculty of Health Sciences, Department of Molecular Medicine, Genome Biology, University of Southern Denmark, Odense M, 5230, Denmark., Selich A; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, 30625, Hannover, Germany., Hagedorn M; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Bastone AL; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Genewity, Oegstgeest, 2342DH, The Netherlands., Schinke M; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany., Dziadek V; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Dittrich-Breiholz O; Research Core Unit Genomics, Hannover Medical School, 30625, Hannover, Germany., von Kaisenberg C; Department of Obstetrics and Gynecology, Hannover Medical School, 30625, Hannover, Germany., Schambach A; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Division of Hematology/Oncology, Department of Pediatric Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rothe M; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany. Rothe.Michael@mh-hannover.de.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany. Rothe.Michael@mh-hannover.de.
Source: Journal of translational medicine [J Transl Med] 2026 Feb 07; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-07700-6