The Sigma1 receptor antagonist CM304 potentiates the antinociceptive effects of the cannabinoid receptor agonist delta9-tetrahydrocannabinol in rats and mice.
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| Title: | The Sigma |
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| Authors: | Zolali E; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA., Burns M; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1225 Center Drive, PO Box 100484, Gainesville, FL, 32610, USA., Intagliata S; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1225 Center Drive, PO Box 100484, Gainesville, FL, 32610, USA.; Department of Drug and Health Sciences, University of Catania, viale A. Doria 6, Catania, 95125, Italy., Patel A; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Ho NP; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Restrepo LF; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Gamez-Jimenez LR; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Alvarez MA; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Wilson LL; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Cutler SJ; College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA., McMahon LR; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Hiranita T; Department of Drug and Health Sciences, University of Catania, viale A. Doria 6, Catania, 95125, Italy.; Department of Pharmacology, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Obeng S; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1225 Center Drive, PO Box 100484, Gainesville, FL, 32610, USA. CMccurdy@cop.ufl.edu.; Translational Drug Development Core, Clinical and Translational Sciences Institute, University of Florida, Gainesville, FL, 32610, USA. CMccurdy@cop.ufl.edu. |
| Source: | Pharmacological reports : PR [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 431-445. Date of Electronic Publication: 2026 Feb 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41656401 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Sigma<subscript>1</subscript> receptor antagonist CM304 potentiates the antinociceptive effects of the cannabinoid receptor agonist delta<superscript>9</superscript>-tetrahydrocannabinol in rats and mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Zolali+E%22">Zolali E</searchLink>; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.<br /><searchLink fieldCode="AU" term="%22Burns+M%22">Burns M</searchLink>; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1225 Center Drive, PO Box 100484, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Intagliata+S%22">Intagliata S</searchLink>; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1225 Center Drive, PO Box 100484, Gainesville, FL, 32610, USA.; Department of Drug and Health Sciences, University of Catania, viale A. Doria 6, Catania, 95125, Italy.<br /><searchLink fieldCode="AU" term="%22Patel+A%22">Patel A</searchLink>; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Ho+NP%22">Ho NP</searchLink>; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Restrepo+LF%22">Restrepo LF</searchLink>; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Gamez-Jimenez+LR%22">Gamez-Jimenez LR</searchLink>; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez+MA%22">Alvarez MA</searchLink>; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+LL%22">Wilson LL</searchLink>; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Cutler+SJ%22">Cutler SJ</searchLink>; College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22McMahon+LR%22">McMahon LR</searchLink>; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22Hiranita+T%22">Hiranita T</searchLink>; Department of Drug and Health Sciences, University of Catania, viale A. Doria 6, Catania, 95125, Italy.; Department of Pharmacology, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Obeng+S%22">Obeng S</searchLink>; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.<br /><searchLink fieldCode="AU" term="%22McCurdy+CR%22">McCurdy CR</searchLink>; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1225 Center Drive, PO Box 100484, Gainesville, FL, 32610, USA. CMccurdy@cop.ufl.edu.; Translational Drug Development Core, Clinical and Translational Sciences Institute, University of Florida, Gainesville, FL, 32610, USA. CMccurdy@cop.ufl.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101234999%22">Pharmacological reports : PR</searchLink> [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 431-445. <i>Date of Electronic Publication: </i>2026 Feb 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101234999 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2299-5684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217341140%22">17341140 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41656401 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s43440-026-00834-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 431 Titles: – TitleFull: The Sigma1 receptor antagonist CM304 potentiates the antinociceptive effects of the cannabinoid receptor agonist delta9-tetrahydrocannabinol in rats and mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zolali E – PersonEntity: Name: NameFull: Burns M – PersonEntity: Name: NameFull: Intagliata S – PersonEntity: Name: NameFull: Patel A – PersonEntity: Name: NameFull: Ho NP – PersonEntity: Name: NameFull: Restrepo LF – PersonEntity: Name: NameFull: Gamez-Jimenez LR – PersonEntity: Name: NameFull: Alvarez MA – PersonEntity: Name: NameFull: Wilson LL – PersonEntity: Name: NameFull: Cutler SJ – PersonEntity: Name: NameFull: McMahon LR – PersonEntity: Name: NameFull: Hiranita T – PersonEntity: Name: NameFull: Obeng S – PersonEntity: Name: NameFull: McCurdy CR IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2299-5684 Numbering: – Type: volume Value: 78 – Type: issue Value: 2 Titles: – TitleFull: Pharmacological reports : PR Type: main |
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