Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics.

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Title: Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics.
Authors: Bai Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Lei H; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Gou S; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Lan J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Cai D; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Zheng X; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China., Shen J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Chen Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Zhao Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Deng S; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Wu X; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Li M; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Xiao Z; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn., Zhang Y; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China. 13795747769@163.com., Du F; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.
Source: Archives of pharmacal research [Arch Pharm Res] 2026 Jan; Vol. 49 (1), pp. 61-100. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article; Review
Journal Info: Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3786 (Electronic) Linking ISSN: 02536269 NLM ISO Abbreviation: Arch Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1976-3786
DOI:10.1007/s12272-026-01595-z