1‑(Phenylselanyl)-2‑(p‑tolyl)indolizine Mitigates Lipopolysaccharide (LPS)-Induced Depressive-Like Behavior by Modulating Oxidative Stress and Inflammatory Markers.

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Title: 1‑(Phenylselanyl)-2‑(p‑tolyl)indolizine Mitigates Lipopolysaccharide (LPS)-Induced Depressive-Like Behavior by Modulating Oxidative Stress and Inflammatory Markers.
Authors: da Rocha MJ; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Presa MH; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Nunes GD; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Barboza VS; Laboratory of Research in Biochemistry and Molecular Biology of Microorganisms, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Giongo JL; Laboratory of Research in Biochemistry and Molecular Biology of Microorganisms, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Vaucher RA; Laboratory of Research in Biochemistry and Molecular Biology of Microorganisms, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Pedra NS; Biomarker Laboratory, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Spanevello RM; Biomarker Laboratory, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Stefanello FM; Biomarker Laboratory, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Gomes CS; Clean Organic Synthesis Laboratory (LASOL), Graduate Program in Chemistry (PPGQ), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Lenardão EJ; Clean Organic Synthesis Laboratory (LASOL), Graduate Program in Chemistry (PPGQ), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Penteado F; Department of Chemistry, Federal University of Santa Maria - UFSM, Av Roraima, Building 18, Santa Maria, RS 97105-900, Brazil., Bortolatto CF; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil., Brüning CA; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas, RS 96010-900, Brazil.
Source: ACS omega [ACS Omega] 2026 Jan 20; Vol. 11 (4), pp. 6578-6590. Date of Electronic Publication: 2026 Jan 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2470-1343
DOI:10.1021/acsomega.5c11651