Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG).
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| Title: | Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG). |
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| Authors: | de Jong AM; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., van der Boog ATJ; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Post CCB; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Cialdella F; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Eekers DBP; Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the Netherlands., Hendrikse J; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Kramer MCA; Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands., Lagerwaard FJ; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands., van der Meulen M; Department of Neurology, Medisch Spectrum Twente, Enschede/ department of Neurology Leiden University Medical Center, Leiden, the Netherlands., Philippens MEP; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Robe PA; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Rozema T; Department of Radiation Oncology, Instituut Verbeeten, Tilburg, the Netherlands., de Vos FYFL; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Vos-Westerman J; Department of Radiation Oncology, Isala Klinieken, Zwolle, the Netherlands., van der Weide HL; Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands., Wester G; Department of Radiation Oncology, Radiotherapiegroep Arnhem, Apeldoorn, Deventer, Ede, the Netherlands., Zindler J; Department of Radiation Oncology, Haaglanden Medisch Centrum, Den Haag, the Netherlands., Snijders TJ; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Verhoeff JJC; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands. |
| Source: | PloS one [PLoS One] 2026 Feb 09; Vol. 21 (2), pp. e0342337. Date of Electronic Publication: 2026 Feb 09 (Print Publication: 2026). |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0342337 |
