Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor.
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| Title: | Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor. |
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| Authors: | Papillon JPN; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Yuan J; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Hesse MJ; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Zhang L; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Robinson RI; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Ware NF; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Hornak V; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Karki RG; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Kirrane T; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Garland K; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Joseph S; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Moquin SA; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.; Global Health, Biomedical Research, Novartis, Emeryville, California 94608, United States., Lakshminarayana SB; Pharmaceutical Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Tandeske L; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Dovala D; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Knapp M; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Ornelas E; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Fuller D; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Ho PI; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Xie X; University of Texas Medical Branch, Galveston, Texas 77555, United States., Vulic K; Technical Research & Development, Development, Novartis, Cambridge, Massachusetts 02139, United States., Skolnik SM; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Gao J; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Zambrowski M; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Spiess M; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Duca JS; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Busby SA; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Schirle M; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Robinson M; Global Health, Biomedical Research, Novartis, Emeryville, California 94608, United States., Shi PY; University of Texas Medical Branch, Galveston, Texas 77555, United States., Moser HE; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Sarko C; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Bradner JE; Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Diagana TT; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Tallarico JA; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 3868-3886. Date of Electronic Publication: 2026 Feb 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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