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Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network.

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Title: Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network.
Authors: Ruiz-Hernández R; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Leioa, Spain.; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain., Gay L; Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK., Moncho-Amor V; Stem Cell Biology and Developmental Genetics Laboratory, The Francis Crick Institute, London, UK.; Biogipuzkoa Health Research Institute, San Sebastián, Spain., Martín P; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Leioa, Spain.; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain., Vergara-Arce JA; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain., Di Blasio S; Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST), University 'G. D'Annunzio', Chieti, Italy., Snoeks T; Biological Research Facility, The Francis Crick Institute, London, UK., Cossío U; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain., Matheu A; Biogipuzkoa Health Research Institute, San Sebastián, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.; Centro de Investigación Biomédica de fragilidad y envejecimiento, CIBERFES, Instituto de Salud Carlos III, Madrid, Spain., Caffarel MM; Biogipuzkoa Health Research Institute, San Sebastián, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain., Gerovska D; Biogipuzkoa Health Research Institute, San Sebastián, Spain., Araúzo-Bravo MJ; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Leioa, Spain.; Biogipuzkoa Health Research Institute, San Sebastián, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain., Vilas A; Department of Hematology-Oncology, Instituto de Investigación Sanitaria de Navarra (IDISNA), CIMA Universidad de Navarra, Pamplona, Spain., Prosper F; Department of Hematology-Oncology, Instituto de Investigación Sanitaria de Navarra (IDISNA), CIMA Universidad de Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain., Moya S; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain., Alonso-Alconada D; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Leioa, Spain., Alonso-Varona A; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Leioa, Spain., Nusspaumer G; Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain., Lopez-Rios J; Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain., Rizotti K; Stem Cell Biology and Developmental Genetics Laboratory, The Francis Crick Institute, London, UK., Lovell-Badge R; Stem Cell Biology and Developmental Genetics Laboratory, The Francis Crick Institute, London, UK., Bonnet D; Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK., Malanchi I; Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK., Abarrategi A; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), Leioa, Spain. ander.abarrategi@ehu.eus.; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastian, Spain. ander.abarrategi@ehu.eus.
Source: Bone research [Bone Res] 2026 Feb 09; Vol. 14 (1), pp. 19. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2095-4700
DOI:10.1038/s41413-025-00500-6