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Severe malaria treatment with rectal artesunate and artemisinin-based combination therapy in remote settings: an effectiveness-implementation hybrid type 3 study protocol (SEMA ReACT).

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Title: Severe malaria treatment with rectal artesunate and artemisinin-based combination therapy in remote settings: an effectiveness-implementation hybrid type 3 study protocol (SEMA ReACT).
Authors: Hachizovu S; National Health Research and Training Institute, Lusaka, Zambia. sebastianhachizovu4@gmail.com.; Global Health Institute, University of Antwerp, Antwerp, Belgium. sebastianhachizovu4@gmail.com., Manyando C; National Health Research and Training Institute, Lusaka, Zambia., Nambozi M; National Health Research and Training Institute, Lusaka, Zambia., Khondowe S; National Health Research and Training Institute, Lusaka, Zambia., Hamainza B; Programme Coordination Unit, Ministry of Health, Lusaka, Zambia., Mukumbuta D; National Malaria Elimination Centre, Ministry of Health, Lusaka, Zambia., Rietveld H; MMV Medicines for Malaria Venture, Geneva, Switzerland., Mukomena Sompwe E; National Malaria Control Programme, Ministry of Health, Kinshasa, Democratic Republic of Congo.; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Kikunda G; National Malaria Control Programme, Lubumbashi, Haut-Katanga Province, Democratic Republic of Congo., Muhindo-Mavoko H; University of Kinshasa, Kinshasa, Democratic Republic of Congo., Luzolo Khote F; Global Health Institute, University of Antwerp, Antwerp, Belgium.; University of Kinshasa, Kinshasa, Democratic Republic of Congo., Kanyamukenge D; Global Health Institute, University of Antwerp, Antwerp, Belgium.; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Bastiaens H; Global Health Institute, University of Antwerp, Antwerp, Belgium., Kakudji A; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Maseko T; Global Health Institute, University of Antwerp, Antwerp, Belgium., Makenga G; Global Health Institute, University of Antwerp, Antwerp, Belgium.; National Institute for Medical Research, Tanga, Tanzania., Baraka V; National Institute for Medical Research, Tanga, Tanzania., Mutombo A; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Duparc S; MMV Medicines for Malaria Venture, Geneva, Switzerland., Van Geertruyden JP; Global Health Institute, University of Antwerp, Antwerp, Belgium.
Source: Malaria journal [Malar J] 2026 Feb 09; Vol. 25 (1). Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Severe malaria treatment with rectal artesunate and artemisinin-based combination therapy in remote settings: an effectiveness-implementation hybrid type 3 study protocol (SEMA ReACT).
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  Data: <searchLink fieldCode="AU" term="%22Hachizovu+S%22">Hachizovu S</searchLink>; National Health Research and Training Institute, Lusaka, Zambia. sebastianhachizovu4@gmail.com.; Global Health Institute, University of Antwerp, Antwerp, Belgium. sebastianhachizovu4@gmail.com.<br /><searchLink fieldCode="AU" term="%22Manyando+C%22">Manyando C</searchLink>; National Health Research and Training Institute, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Nambozi+M%22">Nambozi M</searchLink>; National Health Research and Training Institute, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Khondowe+S%22">Khondowe S</searchLink>; National Health Research and Training Institute, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Hamainza+B%22">Hamainza B</searchLink>; Programme Coordination Unit, Ministry of Health, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Mukumbuta+D%22">Mukumbuta D</searchLink>; National Malaria Elimination Centre, Ministry of Health, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Rietveld+H%22">Rietveld H</searchLink>; MMV Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mukomena+Sompwe+E%22">Mukomena Sompwe E</searchLink>; National Malaria Control Programme, Ministry of Health, Kinshasa, Democratic Republic of Congo.; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Kikunda+G%22">Kikunda G</searchLink>; National Malaria Control Programme, Lubumbashi, Haut-Katanga Province, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Muhindo-Mavoko+H%22">Muhindo-Mavoko H</searchLink>; University of Kinshasa, Kinshasa, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Luzolo+Khote+F%22">Luzolo Khote F</searchLink>; Global Health Institute, University of Antwerp, Antwerp, Belgium.; University of Kinshasa, Kinshasa, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Kanyamukenge+D%22">Kanyamukenge D</searchLink>; Global Health Institute, University of Antwerp, Antwerp, Belgium.; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Bastiaens+H%22">Bastiaens H</searchLink>; Global Health Institute, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Kakudji+A%22">Kakudji A</searchLink>; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Maseko+T%22">Maseko T</searchLink>; Global Health Institute, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Makenga+G%22">Makenga G</searchLink>; Global Health Institute, University of Antwerp, Antwerp, Belgium.; National Institute for Medical Research, Tanga, Tanzania.<br /><searchLink fieldCode="AU" term="%22Baraka+V%22">Baraka V</searchLink>; National Institute for Medical Research, Tanga, Tanzania.<br /><searchLink fieldCode="AU" term="%22Mutombo+A%22">Mutombo A</searchLink>; University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.<br /><searchLink fieldCode="AU" term="%22Duparc+S%22">Duparc S</searchLink>; MMV Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Van+Geertruyden+JP%22">Van Geertruyden JP</searchLink>; Global Health Institute, University of Antwerp, Antwerp, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22101139802%22">Malaria journal</searchLink> [Malar J] 2026 Feb 09; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 Feb 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101139802 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-2875 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752875%22">14752875 </searchLink><i>NLM ISO Abbreviation: </i>Malar J <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12936-026-05816-0
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              Text: 2026 Feb 09
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