Obstacles and improvement strategies for CAR-T cell therapy in solid tumors.

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Title: Obstacles and improvement strategies for CAR-T cell therapy in solid tumors.
Authors: Luo Z; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China., Hu Q; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China., Ren M; School of Nursing, University of South China, Hengyang, Hunan Province, P. R. China., Wang L; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China., Zou Q; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China., Wen X; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China., Chen S; Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219, China., Liu Q; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China., Luo D; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China.; Laboratory Medicine Center, The sixth Affiliated Hospital of Shenzhen University (Nanshan District People's Hospital), Shenzhen, China., Guo Z; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China. guozifen76@163.com.
Source: Discover oncology [Discov Oncol] 2026 Feb 10; Vol. 17 (1), pp. 271. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2730-6011
DOI:10.1007/s12672-026-04473-8