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Obstacles and improvement strategies for CAR-T cell therapy in solid tumors.

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Title: Obstacles and improvement strategies for CAR-T cell therapy in solid tumors.
Authors: Luo Z; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China., Hu Q; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China., Ren M; School of Nursing, University of South China, Hengyang, Hunan Province, P. R. China., Wang L; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China., Zou Q; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China., Wen X; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China., Chen S; Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219, China., Liu Q; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China., Luo D; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China.; Laboratory Medicine Center, The sixth Affiliated Hospital of Shenzhen University (Nanshan District People's Hospital), Shenzhen, China., Guo Z; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China. guozifen76@163.com.
Source: Discover oncology [Discov Oncol] 2026 Feb 10; Vol. 17 (1), pp. 271. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Obstacles and improvement strategies for CAR-T cell therapy in solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Luo+Z%22">Luo Z</searchLink>; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Hu+Q%22">Hu Q</searchLink>; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Ren+M%22">Ren M</searchLink>; School of Nursing, University of South China, Hengyang, Hunan Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zou+Q%22">Zou Q</searchLink>; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wen+X%22">Wen X</searchLink>; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Luo+D%22">Luo D</searchLink>; Laboratory Medicine Center, Shenzhen Luohu Hospital Group, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong Province, P. R. China.; Laboratory Medicine Center, The sixth Affiliated Hospital of Shenzhen University (Nanshan District People's Hospital), Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Guo+Z%22">Guo Z</searchLink>; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan Province, P. R. China. guozifen76@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101775142%22">Discover oncology</searchLink> [Discov Oncol] 2026 Feb 10; Vol. 17 (1), pp. 271. <i>Date of Electronic Publication: </i>2026 Feb 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101775142 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-6011 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227306011%22">27306011 </searchLink><i>NLM ISO Abbreviation: </i>Discov Oncol <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41665753
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              Text: 2026 Feb 10
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