Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.
Saved in:
| Title: | Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy. |
|---|---|
| Authors: | Schinke C; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany. christian.schinke@charite.de.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany. christian.schinke@charite.de., Maierhof SK; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany., Hew L; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany., Fernandez Vallone V; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Pluripotent Stem Cells and Organoids (CUSCO), Berlin, Germany., Frahm S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Telugu NS; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Diecke S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Ivanov A; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany., Kovács R; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institut für Neurophysiologie, Berlin, Germany., Beule D; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany., Kirchner M; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany., Mertins P; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany., Brüning U; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Kirwan JA; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; University of Veterinary Medicine, Vienna, Wien, Austria., Stachelscheid H; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Pluripotent Stem Cells and Organoids (CUSCO), Berlin, Germany., Endres M; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Germany.; German Center for Mental Health (DZPG), Berlin, Germany., Huehnchen P; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany., Boehmerle W; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Feb 10; Vol. 17 (1), pp. 211. Date of Electronic Publication: 2026 Feb 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 2041-4889 |
|---|---|
| DOI: | 10.1038/s41419-026-08445-2 |
