View in EDS HTML Full Text PDF Full Text

Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.

Saved in:
Bibliographic Details
Title: Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.
Authors: Schinke C; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany. christian.schinke@charite.de.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany. christian.schinke@charite.de., Maierhof SK; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany., Hew L; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany., Fernandez Vallone V; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Pluripotent Stem Cells and Organoids (CUSCO), Berlin, Germany., Frahm S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Telugu NS; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Diecke S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Ivanov A; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany., Kovács R; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institut für Neurophysiologie, Berlin, Germany., Beule D; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany., Kirchner M; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany., Mertins P; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany., Brüning U; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Kirwan JA; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; University of Veterinary Medicine, Vienna, Wien, Austria., Stachelscheid H; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Pluripotent Stem Cells and Organoids (CUSCO), Berlin, Germany., Endres M; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Germany.; German Center for Mental Health (DZPG), Berlin, Germany., Huehnchen P; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany., Boehmerle W; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 10; Vol. 17 (1), pp. 211. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41667428
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Schinke+C%22">Schinke C</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany. christian.schinke@charite.de.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany. christian.schinke@charite.de.<br /><searchLink fieldCode="AU" term="%22Maierhof+SK%22">Maierhof SK</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hew+L%22">Hew L</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Fernandez+Vallone+V%22">Fernandez Vallone V</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Pluripotent Stem Cells and Organoids (CUSCO), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Frahm+S%22">Frahm S</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Telugu+NS%22">Telugu NS</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Diecke+S%22">Diecke S</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ivanov+A%22">Ivanov A</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kovács+R%22">Kovács R</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institut für Neurophysiologie, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Beule+D%22">Beule D</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kirchner+M%22">Kirchner M</searchLink>; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mertins+P%22">Mertins P</searchLink>; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Brüning+U%22">Brüning U</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kirwan+JA%22">Kirwan JA</searchLink>; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; University of Veterinary Medicine, Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Stachelscheid+H%22">Stachelscheid H</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Core Unit Pluripotent Stem Cells and Organoids (CUSCO), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Endres+M%22">Endres M</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Berlin, Germany.; German Center for Mental Health (DZPG), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Huehnchen+P%22">Huehnchen P</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Boehmerle+W%22">Boehmerle W</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Feb 10; Vol. 17 (1), pp. 211. <i>Date of Electronic Publication: </i>2026 Feb 10.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41667428
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41419-026-08445-2
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 211
    Titles:
      – TitleFull: Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Schinke C
      – PersonEntity:
          Name:
            NameFull: Maierhof SK
      – PersonEntity:
          Name:
            NameFull: Hew L
      – PersonEntity:
          Name:
            NameFull: Fernandez Vallone V
      – PersonEntity:
          Name:
            NameFull: Frahm S
      – PersonEntity:
          Name:
            NameFull: Telugu NS
      – PersonEntity:
          Name:
            NameFull: Diecke S
      – PersonEntity:
          Name:
            NameFull: Ivanov A
      – PersonEntity:
          Name:
            NameFull: Kovács R
      – PersonEntity:
          Name:
            NameFull: Beule D
      – PersonEntity:
          Name:
            NameFull: Kirchner M
      – PersonEntity:
          Name:
            NameFull: Mertins P
      – PersonEntity:
          Name:
            NameFull: Brüning U
      – PersonEntity:
          Name:
            NameFull: Kirwan JA
      – PersonEntity:
          Name:
            NameFull: Stachelscheid H
      – PersonEntity:
          Name:
            NameFull: Endres M
      – PersonEntity:
          Name:
            NameFull: Huehnchen P
      – PersonEntity:
          Name:
            NameFull: Boehmerle W
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 10
              M: 02
              Text: 2026 Feb 10
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-4889
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Cell death & disease
              Type: main
ResultId 1