An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models.
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| Title: | An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models. |
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| Authors: | Ontoria JM; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy. j.ontoria@irbm.com., Torrente E; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Missineo A; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Alli C; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Graziani R; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Conti S; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Bisbocci M; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Quotadamo A; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Ferrigno F; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Corio A; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Ievoli G; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Bencheva L; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Sibylla Biotech S.p.A., Bresso, Italy., Amaudrut J; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Vasile S; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Beghetto E; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Paolini C; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Alaimo N; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Veneziano M; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Nibbio M; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Orsale MV; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Proto G; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Colaceci F; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Orsatti L; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Pucci V; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Johnson & Johnson, Beerse, Belgium., Di Fabio R; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Drug Discovery Unit, Vita Salute San Raffaele University, Milan, Italy., Tomei L; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Montalbetti C; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Bresciani A; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.; Tycho S.r.l., Bergamo, Italy., Toniatti C; CSO, IRBM S.p.A., Pomezia, Italy., Paonessa G; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy. g.paonessa@irbm.com. |
| Source: | Nature communications [Nat Commun] 2026 Feb 10; Vol. 17 (1), pp. 1439. Date of Electronic Publication: 2026 Feb 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-68943-x |
