IL-4-STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing.

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Title: IL-4-STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing.
Authors: Maurice NJ; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu., Dalzell TS; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Tankersley TN; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Rhee KH; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Block KE; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Jarjour NN; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.; Versiti Blood Research Institute, Milwaukee, WI, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., DePauw TA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Wall SM; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Hamilton SE; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Jameson SC; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.
Source: Nature immunology [Nat Immunol] 2026 Mar; Vol. 27 (3), pp. 476-489. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1529-2916
DOI:10.1038/s41590-026-02430-9