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IL-4-STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing.

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Title: IL-4-STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing.
Authors: Maurice NJ; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu., Dalzell TS; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Tankersley TN; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Rhee KH; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Block KE; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Jarjour NN; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.; Versiti Blood Research Institute, Milwaukee, WI, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., DePauw TA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Wall SM; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Hamilton SE; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Jameson SC; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.
Source: Nature immunology [Nat Immunol] 2026 Mar; Vol. 27 (3), pp. 476-489. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: IL-4-STAT6 signaling delays protective CD8<superscript>+</superscript> T cell bystander activation by antagonizing IL-18 sensing.
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  Data: <searchLink fieldCode="AU" term="%22Maurice+NJ%22">Maurice NJ</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu.<br /><searchLink fieldCode="AU" term="%22Dalzell+TS%22">Dalzell TS</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Tankersley+TN%22">Tankersley TN</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Rhee+KH%22">Rhee KH</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Block+KE%22">Block KE</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jarjour+NN%22">Jarjour NN</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.; Versiti Blood Research Institute, Milwaukee, WI, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22DePauw+TA%22">DePauw TA</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Wall+SM%22">Wall SM</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+SE%22">Hamilton SE</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jameson+SC%22">Jameson SC</searchLink>; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Mar; Vol. 27 (3), pp. 476-489. <i>Date of Electronic Publication: </i>2026 Feb 10.
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