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Low CD3+ and CD4+ T cell levels predict need for ventilatory support and in-hospital mortality in patients with COVID-19: a retrospective cohort study.

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Title: Low CD3+ and CD4+ T cell levels predict need for ventilatory support and in-hospital mortality in patients with COVID-19: a retrospective cohort study.
Authors: Martínez EL; Department of Internal Medicine, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain., Moreno-Pérez Ó; Department of Endocrinology and Nutrition, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain., Otero-Rodríguez S; Infectious Diseases Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain., García-Sevila R; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.; Department of Pneumology, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain., Marco-de-la-Calle F; Department of Immunology, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain., Sánchez-Martínez R; Department of Internal Medicine, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain., Merino-de-Lucas E; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.; Infectious Diseases Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain., Ramos-Rincón JM; Department of Internal Medicine, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.
Source: Frontiers in medicine [Front Med (Lausanne)] 2026 Jan 26; Vol. 13, pp. 1740358. Date of Electronic Publication: 2026 Jan 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Low CD3+ and CD4+ T cell levels predict need for ventilatory support and in-hospital mortality in patients with COVID-19: a retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Martínez+EL%22">Martínez EL</searchLink>; Department of Internal Medicine, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno-Pérez+Ó%22">Moreno-Pérez Ó</searchLink>; Department of Endocrinology and Nutrition, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Otero-Rodríguez+S%22">Otero-Rodríguez S</searchLink>; Infectious Diseases Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22García-Sevila+R%22">García-Sevila R</searchLink>; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.; Department of Pneumology, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Marco-de-la-Calle+F%22">Marco-de-la-Calle F</searchLink>; Department of Immunology, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Martínez+R%22">Sánchez-Martínez R</searchLink>; Department of Internal Medicine, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Merino-de-Lucas+E%22">Merino-de-Lucas E</searchLink>; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.; Infectious Diseases Unit, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos-Rincón+JM%22">Ramos-Rincón JM</searchLink>; Department of Internal Medicine, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, Alicante, Spain.; Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101648047%22">Frontiers in medicine</searchLink> [Front Med (Lausanne)] 2026 Jan 26; Vol. 13, pp. 1740358. <i>Date of Electronic Publication: </i>2026 Jan 26 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2EA%22">Frontiers Media S.A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101648047 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2296-858X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222296858X%22">2296858X </searchLink><i>NLM ISO Abbreviation: </i>Front Med (Lausanne) <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Jan 26
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