View in EDS

Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO.

Saved in:
Bibliographic Details
Title: Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO.
Authors: Li Z; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. zifan.li@biogen.com., Nguyen T; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA., Zhou X; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA., Xiao L; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA., Bou-Assaf GM; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. george.bou-assaf@biogen.com.
Source: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2026 Apr; Vol. 418 (8), pp. 2415-2425. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41670633
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. zifan.li@biogen.com.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Bou-Assaf+GM%22">Bou-Assaf GM</searchLink>; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. george.bou-assaf@biogen.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101134327%22">Analytical and bioanalytical chemistry</searchLink> [Anal Bioanal Chem] 2026 Apr; Vol. 418 (8), pp. 2415-2425. <i>Date of Electronic Publication: </i>2026 Feb 11.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101134327 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-2650 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216182642%22">16182642 </searchLink><i>NLM ISO Abbreviation: </i>Anal Bioanal Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41670633
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00216-026-06370-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2415
    Titles:
      – TitleFull: Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Li Z
      – PersonEntity:
          Name:
            NameFull: Nguyen T
      – PersonEntity:
          Name:
            NameFull: Zhou X
      – PersonEntity:
          Name:
            NameFull: Xiao L
      – PersonEntity:
          Name:
            NameFull: Bou-Assaf GM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1618-2650
          Numbering:
            – Type: volume
              Value: 418
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Analytical and bioanalytical chemistry
              Type: main
ResultId 1