Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.

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Title: Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.
Authors: Hendifar AE; Cedars Sinai Medical Center, Los Angeles, CA., Krishna V; Valar Labs, Inc, Palo Alto, CA., Krishna V; Valar Labs, Inc, Palo Alto, CA., Zhang H; Valar Labs, Inc, Palo Alto, CA., Tarsode A; Valar Labs, Inc, Palo Alto, CA., Nimgaonkar V; Valar Labs, Inc, Palo Alto, CA.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD., Smith K; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA., Abdilleh K; Pancreatic Cancer Action Network, El Segundo, CA., Sonawane S; Valar Labs, Inc, Palo Alto, CA.; University of Illinois at Chicago, Chicago, IL., Neema A; Valar Labs, Inc, Palo Alto, CA., Tiu E; Valar Labs, Inc, Palo Alto, CA., Larson BK; Cedars Sinai Medical Center, Los Angeles, CA., Kazarov V; Cedars Sinai Medical Center, Los Angeles, CA., Moshayedi N; Cedars Sinai Medical Center, Los Angeles, CA., Hutchinson S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Bevacqua D; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Doss S; Pancreatic Cancer Action Network, El Segundo, CA., Alvarez A; Pancreatic Cancer Action Network, El Segundo, CA., Watson D; Valar Labs, Inc, Palo Alto, CA., Abuzeid WM; Valar Labs, Inc, Palo Alto, CA., Grünwald BT; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Urology, University Hospital Essen, Essen, Germany.; West German Cancer Center, Essen, Germany., Noel M; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC., Samdani R; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC., Keith D; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR., Sears RC; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR., Sohal D; Department of Hematology & Oncology, University of Cincinnati Cancer Center, Cincinnati, OH., Fountzilas C; Roswell Park Comprehensive Cancer Center, Buffalo, NY., O'Kane GM; Department of Medical Oncology, St Vincent's University Hospital, School of Medicine, University College, Dublin, Ireland., Grant RC; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Osipov A; Cedars Sinai Medical Center, Los Angeles, CA., Collisson EA; Fred Hutchinson Cancer Center, Seattle, WA., Kiedrowski LA; Valar Labs, Inc, Palo Alto, CA., Royce TJ; Valar Labs, Inc, Palo Alto, CA.; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC., Joshi AR; Valar Labs, Inc, Palo Alto, CA., Singhi AD; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA., Knox JJ; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Feb 11, pp. JCO2502199. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1527-7755
DOI:10.1200/JCO-25-02199