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Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.

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Title: Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.
Authors: Hendifar AE; Cedars Sinai Medical Center, Los Angeles, CA., Krishna V; Valar Labs, Inc, Palo Alto, CA., Krishna V; Valar Labs, Inc, Palo Alto, CA., Zhang H; Valar Labs, Inc, Palo Alto, CA., Tarsode A; Valar Labs, Inc, Palo Alto, CA., Nimgaonkar V; Valar Labs, Inc, Palo Alto, CA.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD., Smith K; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA., Abdilleh K; Pancreatic Cancer Action Network, El Segundo, CA., Sonawane S; Valar Labs, Inc, Palo Alto, CA.; University of Illinois at Chicago, Chicago, IL., Neema A; Valar Labs, Inc, Palo Alto, CA., Tiu E; Valar Labs, Inc, Palo Alto, CA., Larson BK; Cedars Sinai Medical Center, Los Angeles, CA., Kazarov V; Cedars Sinai Medical Center, Los Angeles, CA., Moshayedi N; Cedars Sinai Medical Center, Los Angeles, CA., Hutchinson S; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Bevacqua D; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Doss S; Pancreatic Cancer Action Network, El Segundo, CA., Alvarez A; Pancreatic Cancer Action Network, El Segundo, CA., Watson D; Valar Labs, Inc, Palo Alto, CA., Abuzeid WM; Valar Labs, Inc, Palo Alto, CA., Grünwald BT; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Urology, University Hospital Essen, Essen, Germany.; West German Cancer Center, Essen, Germany., Noel M; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC., Samdani R; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC., Keith D; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR., Sears RC; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR., Sohal D; Department of Hematology & Oncology, University of Cincinnati Cancer Center, Cincinnati, OH., Fountzilas C; Roswell Park Comprehensive Cancer Center, Buffalo, NY., O'Kane GM; Department of Medical Oncology, St Vincent's University Hospital, School of Medicine, University College, Dublin, Ireland., Grant RC; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Osipov A; Cedars Sinai Medical Center, Los Angeles, CA., Collisson EA; Fred Hutchinson Cancer Center, Seattle, WA., Kiedrowski LA; Valar Labs, Inc, Palo Alto, CA., Royce TJ; Valar Labs, Inc, Palo Alto, CA.; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC., Joshi AR; Valar Labs, Inc, Palo Alto, CA., Singhi AD; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA., Knox JJ; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Feb 11, pp. JCO2502199. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Development and Validation of a Computational Histology Artificial Intelligence-Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Hendifar+AE%22">Hendifar AE</searchLink>; Cedars Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Krishna+V%22">Krishna V</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Krishna+V%22">Krishna V</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Tarsode+A%22">Tarsode A</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Nimgaonkar+V%22">Nimgaonkar V</searchLink>; Valar Labs, Inc, Palo Alto, CA.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Smith+K%22">Smith K</searchLink>; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Abdilleh+K%22">Abdilleh K</searchLink>; Pancreatic Cancer Action Network, El Segundo, CA.<br /><searchLink fieldCode="AU" term="%22Sonawane+S%22">Sonawane S</searchLink>; Valar Labs, Inc, Palo Alto, CA.; University of Illinois at Chicago, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Neema+A%22">Neema A</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Tiu+E%22">Tiu E</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Larson+BK%22">Larson BK</searchLink>; Cedars Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Kazarov+V%22">Kazarov V</searchLink>; Cedars Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Moshayedi+N%22">Moshayedi N</searchLink>; Cedars Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Hutchinson+S%22">Hutchinson S</searchLink>; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bevacqua+D%22">Bevacqua D</searchLink>; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Doss+S%22">Doss S</searchLink>; Pancreatic Cancer Action Network, El Segundo, CA.<br /><searchLink fieldCode="AU" term="%22Alvarez+A%22">Alvarez A</searchLink>; Pancreatic Cancer Action Network, El Segundo, CA.<br /><searchLink fieldCode="AU" term="%22Watson+D%22">Watson D</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Abuzeid+WM%22">Abuzeid WM</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Grünwald+BT%22">Grünwald BT</searchLink>; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Urology, University Hospital Essen, Essen, Germany.; West German Cancer Center, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Noel+M%22">Noel M</searchLink>; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Samdani+R%22">Samdani R</searchLink>; Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Keith+D%22">Keith D</searchLink>; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Sears+RC%22">Sears RC</searchLink>; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Sohal+D%22">Sohal D</searchLink>; Department of Hematology & Oncology, University of Cincinnati Cancer Center, Cincinnati, OH.<br /><searchLink fieldCode="AU" term="%22Fountzilas+C%22">Fountzilas C</searchLink>; Roswell Park Comprehensive Cancer Center, Buffalo, NY.<br /><searchLink fieldCode="AU" term="%22O'Kane+GM%22">O'Kane GM</searchLink>; Department of Medical Oncology, St Vincent's University Hospital, School of Medicine, University College, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Grant+RC%22">Grant RC</searchLink>; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Osipov+A%22">Osipov A</searchLink>; Cedars Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Collisson+EA%22">Collisson EA</searchLink>; Fred Hutchinson Cancer Center, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Kiedrowski+LA%22">Kiedrowski LA</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Royce+TJ%22">Royce TJ</searchLink>; Valar Labs, Inc, Palo Alto, CA.; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC.<br /><searchLink fieldCode="AU" term="%22Joshi+AR%22">Joshi AR</searchLink>; Valar Labs, Inc, Palo Alto, CA.<br /><searchLink fieldCode="AU" term="%22Singhi+AD%22">Singhi AD</searchLink>; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Knox+JJ%22">Knox JJ</searchLink>; Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2026 Feb 11, pp. JCO2502199. <i>Date of Electronic Publication: </i>2026 Feb 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE
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