Targeting excessive cholesterol deposition alleviates secondary lymphoedema.

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Title: Targeting excessive cholesterol deposition alleviates secondary lymphoedema.
Authors: Lim HY; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Zhang Y; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Azhar SHM; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Thiam CH; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Taylor M; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Koh XH; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Yunos MASBM; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Tan SW; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim SY; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Ong WS; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Goh J; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Ng SH; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Cochran BJ; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Tham WK; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Ang O; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim SJ; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim TC; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Chen Y; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Mause SF; Department of Internal Medicine I, Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Torta F; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore., Wenk MR; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Rye KA; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Tan BK; Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General hospital, Singapore, Singapore.; Musculoskeletal Sciences Academic Clinical Programmes, Duke-NUS Medical School, Singapore, Singapore., Angeli V; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.; Université Côte d'Azur, Inserm, C3M, Nice, France. veronique.angeli@univ-cotedazur.fr.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8105), pp. 462-471. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-10016-y