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Targeting excessive cholesterol deposition alleviates secondary lymphoedema.

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Title: Targeting excessive cholesterol deposition alleviates secondary lymphoedema.
Authors: Lim HY; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Zhang Y; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Azhar SHM; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Thiam CH; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Taylor M; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Koh XH; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Yunos MASBM; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Tan SW; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim SY; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Ong WS; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Goh J; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Ng SH; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Cochran BJ; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Tham WK; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Ang O; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim SJ; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Lim TC; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Chen Y; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Mause SF; Department of Internal Medicine I, Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Torta F; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore., Wenk MR; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Rye KA; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Tan BK; Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General hospital, Singapore, Singapore.; Musculoskeletal Sciences Academic Clinical Programmes, Duke-NUS Medical School, Singapore, Singapore., Angeli V; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.; Université Côte d'Azur, Inserm, C3M, Nice, France. veronique.angeli@univ-cotedazur.fr.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8105), pp. 462-471. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Targeting excessive cholesterol deposition alleviates secondary lymphoedema.
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  Data: <searchLink fieldCode="AU" term="%22Lim+HY%22">Lim HY</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Azhar+SHM%22">Azhar SHM</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Thiam+CH%22">Thiam CH</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Taylor+M%22">Taylor M</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Koh+XH%22">Koh XH</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yunos+MASBM%22">Yunos MASBM</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+SW%22">Tan SW</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+SY%22">Lim SY</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+WS%22">Ong WS</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+J%22">Goh J</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+SH%22">Ng SH</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cochran+BJ%22">Cochran BJ</searchLink>; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Tham+WK%22">Tham WK</searchLink>; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ang+O%22">Ang O</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+SJ%22">Lim SJ</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+TC%22">Lim TC</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Mause+SF%22">Mause SF</searchLink>; Department of Internal Medicine I, Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Torta+F%22">Torta F</searchLink>; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wenk+MR%22">Wenk MR</searchLink>; Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Rye+KA%22">Rye KA</searchLink>; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Tan+BK%22">Tan BK</searchLink>; Department of Plastic, Reconstructive and Aesthetic Surgery, Singapore General hospital, Singapore, Singapore.; Musculoskeletal Sciences Academic Clinical Programmes, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Angeli+V%22">Angeli V</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.; Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore. veronique.angeli@univ-cotedazur.fr.; Université Côte d'Azur, Inserm, C3M, Nice, France. veronique.angeli@univ-cotedazur.fr.
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