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High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner.

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Title: High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner.
Authors: James D; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Batool M; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Poveda C; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Hayirli Z; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Callow C; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Abbas M; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Cancer Research @UCC, College of Medicine and Health, University College Cork, Cork, Ireland., Linden B; Department of Nutrition, Food & Exercise Sciences, University of Surrey, Guildford, GU2 7XH, UK., Gibson J; Food and Feed Innovations, Newcastle Rd, Wore, N Shropshire, Woodstock, CW3 95N, UK., Griffin BA; Department of Nutrition, Food & Exercise Sciences, University of Surrey, Guildford, GU2 7XH, UK., Elmore JS; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Walton GE; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK., Robertson MD; Department of Nutrition, Food & Exercise Sciences, University of Surrey, Guildford, GU2 7XH, UK., Lewis MC; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK. marie.lewis@reading.ac.uk.
Source: European journal of nutrition [Eur J Nutr] 2026 Feb 12; Vol. 65 (2), pp. 41. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner.
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  Data: <searchLink fieldCode="AU" term="%22James+D%22">James D</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Batool+M%22">Batool M</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Poveda+C%22">Poveda C</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Hayirli+Z%22">Hayirli Z</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Callow+C%22">Callow C</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Abbas+M%22">Abbas M</searchLink>; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Cancer Research @UCC, College of Medicine and Health, University College Cork, Cork, Ireland.<br /><searchLink fieldCode="AU" term="%22Linden+B%22">Linden B</searchLink>; Department of Nutrition, Food & Exercise Sciences, University of Surrey, Guildford, GU2 7XH, UK.<br /><searchLink fieldCode="AU" term="%22Gibson+J%22">Gibson J</searchLink>; Food and Feed Innovations, Newcastle Rd, Wore, N Shropshire, Woodstock, CW3 95N, UK.<br /><searchLink fieldCode="AU" term="%22Griffin+BA%22">Griffin BA</searchLink>; Department of Nutrition, Food & Exercise Sciences, University of Surrey, Guildford, GU2 7XH, UK.<br /><searchLink fieldCode="AU" term="%22Elmore+JS%22">Elmore JS</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Walton+GE%22">Walton GE</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK.<br /><searchLink fieldCode="AU" term="%22Robertson+MD%22">Robertson MD</searchLink>; Department of Nutrition, Food & Exercise Sciences, University of Surrey, Guildford, GU2 7XH, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+MC%22">Lewis MC</searchLink>; Department of Food and Nutritional Sciences, Whiteknights Campus, University of Reading, Reading, RG6 6DZ, UK. marie.lewis@reading.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22100888704%22">European journal of nutrition</searchLink> [Eur J Nutr] 2026 Feb 12; Vol. 65 (2), pp. 41. <i>Date of Electronic Publication: </i>2026 Feb 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Steinkopff%22">Steinkopff </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>100888704 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1436-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214366207%22">14366207 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Nutr <i>Subsets: </i>MEDLINE
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