ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation.
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| Title: | ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation. |
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| Authors: | Dhaliwal NK; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Weng OY; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Tian A; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Aggarwal A; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Ahmed M; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Sun G; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Bhattacharya A; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Choi WWY; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Nishimura H; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Chakraborty P; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Dong X; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China., Wu Y; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Wang LY; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Parada LF; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York NY 10065.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Muffat J; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Li Y; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Feb 17; Vol. 123 (7), pp. e2523367123. Date of Electronic Publication: 2026 Feb 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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