Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease.
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| Title: | Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. |
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| Authors: | Raschdorf A; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Annika.Raschdorf@uksh.de., de Almeida LN; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Solbach P; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Kirstein MM; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Marquardt JU; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Schmelter F; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Günther UL; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany., Schlichting H; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Hicken M; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Christiansen L; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Wiestler M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Tews HC; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany., Bettenworth D; CED Schwerpunktpraxis, Münster, Germany.; Medical Faculty, University of Münster, Münster, Germany., Peipp M; Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany., Valerius T; Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany., Ragab M; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Department of Internal Medicine II, Rechts der Isar Hospital, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Sauer T; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Gemoll T; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Ehlers M; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Airway Research Center North, University of Lübeck, German Center for Lung Research, Lübeck, Germany., Rosenstiel P; Institute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Manz RA; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Künstner A; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Busch H; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Sina C; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Derer S; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Stefanie.Derer@uksh.de. |
| Corporate Authors: | OUTLIVE-CRC consortium |
| Source: | Nature communications [Nat Commun] 2026 Feb 12; Vol. 17 (1), pp. 1590. Date of Electronic Publication: 2026 Feb 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-69069-w |
