Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease.
Saved in:
| Title: | Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. |
|---|---|
| Authors: | Raschdorf A; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Annika.Raschdorf@uksh.de., de Almeida LN; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Solbach P; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Kirstein MM; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Marquardt JU; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Schmelter F; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Günther UL; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany., Schlichting H; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Hicken M; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Christiansen L; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Wiestler M; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Tews HC; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany., Bettenworth D; CED Schwerpunktpraxis, Münster, Germany.; Medical Faculty, University of Münster, Münster, Germany., Peipp M; Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany., Valerius T; Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany., Ragab M; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Department of Internal Medicine II, Rechts der Isar Hospital, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Sauer T; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Gemoll T; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Ehlers M; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Airway Research Center North, University of Lübeck, German Center for Lung Research, Lübeck, Germany., Rosenstiel P; Institute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany., Manz RA; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Künstner A; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Busch H; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Sina C; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Derer S; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Stefanie.Derer@uksh.de. |
| Corporate Authors: | OUTLIVE-CRC consortium |
| Source: | Nature communications [Nat Commun] 2026 Feb 12; Vol. 17 (1), pp. 1590. Date of Electronic Publication: 2026 Feb 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41680132 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Raschdorf+A%22">Raschdorf A</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Annika.Raschdorf@uksh.de.<br /><searchLink fieldCode="AU" term="%22de+Almeida+LN%22">de Almeida LN</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Solbach+P%22">Solbach P</searchLink>; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Kirstein+MM%22">Kirstein MM</searchLink>; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Marquardt+JU%22">Marquardt JU</searchLink>; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Schmelter+F%22">Schmelter F</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Günther+UL%22">Günther UL</searchLink>; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Schlichting+H%22">Schlichting H</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Hicken+M%22">Hicken M</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Christiansen+L%22">Christiansen L</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Wiestler+M%22">Wiestler M</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Tews+HC%22">Tews HC</searchLink>; Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bettenworth+D%22">Bettenworth D</searchLink>; CED Schwerpunktpraxis, Münster, Germany.; Medical Faculty, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Peipp+M%22">Peipp M</searchLink>; Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Valerius+T%22">Valerius T</searchLink>; Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Ragab+M%22">Ragab M</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Department of Internal Medicine II, Rechts der Isar Hospital, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sauer+T%22">Sauer T</searchLink>; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Gemoll+T%22">Gemoll T</searchLink>; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ehlers+M%22">Ehlers M</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Airway Research Center North, University of Lübeck, German Center for Lung Research, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenstiel+P%22">Rosenstiel P</searchLink>; Institute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Manz+RA%22">Manz RA</searchLink>; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Künstner+A%22">Künstner A</searchLink>; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Busch+H%22">Busch H</searchLink>; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Sina+C%22">Sina C</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; 1st Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Derer+S%22">Derer S</searchLink>; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Stefanie.Derer@uksh.de. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22OUTLIVE-CRC+consortium%22">OUTLIVE-CRC consortium</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 12; Vol. 17 (1), pp. 1590. <i>Date of Electronic Publication: </i>2026 Feb 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41680132 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-69069-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1590 Titles: – TitleFull: Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Raschdorf A – PersonEntity: Name: NameFull: de Almeida LN – PersonEntity: Name: NameFull: Solbach P – PersonEntity: Name: NameFull: Kirstein MM – PersonEntity: Name: NameFull: Marquardt JU – PersonEntity: Name: NameFull: Schmelter F – PersonEntity: Name: NameFull: Günther UL – PersonEntity: Name: NameFull: Schlichting H – PersonEntity: Name: NameFull: Hicken M – PersonEntity: Name: NameFull: Christiansen L – PersonEntity: Name: NameFull: Wiestler M – PersonEntity: Name: NameFull: Tews HC – PersonEntity: Name: NameFull: Bettenworth D – PersonEntity: Name: NameFull: Peipp M – PersonEntity: Name: NameFull: Valerius T – PersonEntity: Name: NameFull: Ragab M – PersonEntity: Name: NameFull: Sauer T – PersonEntity: Name: NameFull: Gemoll T – PersonEntity: Name: NameFull: Ehlers M – PersonEntity: Name: NameFull: Rosenstiel P – PersonEntity: Name: NameFull: Manz RA – PersonEntity: Name: NameFull: Künstner A – PersonEntity: Name: NameFull: Busch H – PersonEntity: Name: NameFull: Sina C – PersonEntity: Name: NameFull: Derer S IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 02 Text: 2026 Feb 12 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
| ResultId | 1 |
