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Targeting the C/EBPβ-PRAME-EZH2 complex modulates the Netrin-4/AKT axis to inhibit renal cancer tumorigenesis and metastasis.

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Title: Targeting the C/EBPβ-PRAME-EZH2 complex modulates the Netrin-4/AKT axis to inhibit renal cancer tumorigenesis and metastasis.
Authors: Zhang LZ; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. zhanglzh3@mail2.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. zhanglzh3@mail2.sysu.edu.cn., Zhang ZK; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Fu LM; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Zhu E; The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong, China., Huang C; Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China., Lin HS; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Gui CP; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Huang GW; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Chen ZH; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Chen W; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guo JP; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. guojp6@mail.sysu.edu.cn., Wei JH; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. weijh23@mail.sysu.edu.cn., Luo JH; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. luojunh@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. luojunh@mail.sysu.edu.cn.
Source: Cell death and differentiation [Cell Death Differ] 2026 Feb 12. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+LZ%22">Zhang LZ</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. zhanglzh3@mail2.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. zhanglzh3@mail2.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+ZK%22">Zhang ZK</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Fu+LM%22">Fu LM</searchLink>; Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zhu+E%22">Zhu E</searchLink>; The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Lin+HS%22">Lin HS</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Gui+CP%22">Gui CP</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Huang+GW%22">Huang GW</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+ZH%22">Chen ZH</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Guo+JP%22">Guo JP</searchLink>; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. guojp6@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wei+JH%22">Wei JH</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. weijh23@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Luo+JH%22">Luo JH</searchLink>; Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. luojunh@mail.sysu.edu.cn.; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. luojunh@mail.sysu.edu.cn.
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              Text: 2026 Feb 12
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