Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation.

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Title: Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation.
Authors: Spanke VA; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Egger-Hoerschinger VJ; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Seidler CA; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Kroell KB; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Wieser V; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Imhof-Jung S; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Weiche B; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Bujotzek A; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Georges G; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Liedl KR; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Source: MAbs [MAbs] 2026 Dec 31; Vol. 18 (1), pp. 2627669. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1942-0870
DOI:10.1080/19420862.2026.2627669