View in EDS

Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation.

Saved in:
Bibliographic Details
Title: Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation.
Authors: Spanke VA; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Egger-Hoerschinger VJ; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Seidler CA; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Kroell KB; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Wieser V; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Imhof-Jung S; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Weiche B; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Bujotzek A; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Georges G; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany., Liedl KR; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Source: MAbs [MAbs] 2026 Dec 31; Vol. 18 (1), pp. 2627669. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41684328
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Spanke+VA%22">Spanke VA</searchLink>; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Egger-Hoerschinger+VJ%22">Egger-Hoerschinger VJ</searchLink>; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Seidler+CA%22">Seidler CA</searchLink>; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Kroell+KB%22">Kroell KB</searchLink>; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wieser+V%22">Wieser V</searchLink>; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Imhof-Jung+S%22">Imhof-Jung S</searchLink>; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weiche+B%22">Weiche B</searchLink>; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bujotzek+A%22">Bujotzek A</searchLink>; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Georges+G%22">Georges G</searchLink>; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Liedl+KR%22">Liedl KR</searchLink>; Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101479829%22">MAbs</searchLink> [MAbs] 2026 Dec 31; Vol. 18 (1), pp. 2627669. <i>Date of Electronic Publication: </i>2026 Feb 13.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101479829 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1942-0870 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219420862%22">19420862 </searchLink><i>NLM ISO Abbreviation: </i>MAbs <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41684328
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/19420862.2026.2627669
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2627669
    Titles:
      – TitleFull: Balancing the extremes for antibody developability: hydrophobic and electrostatic germline framework signatures for CDR-loop compensation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Spanke VA
      – PersonEntity:
          Name:
            NameFull: Egger-Hoerschinger VJ
      – PersonEntity:
          Name:
            NameFull: Seidler CA
      – PersonEntity:
          Name:
            NameFull: Kroell KB
      – PersonEntity:
          Name:
            NameFull: Wieser V
      – PersonEntity:
          Name:
            NameFull: Imhof-Jung S
      – PersonEntity:
          Name:
            NameFull: Weiche B
      – PersonEntity:
          Name:
            NameFull: Bujotzek A
      – PersonEntity:
          Name:
            NameFull: Georges G
      – PersonEntity:
          Name:
            NameFull: Liedl KR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 31
              M: 12
              Text: 2026 Dec 31
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1942-0870
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: MAbs
              Type: main
ResultId 1