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WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.

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Bibliographic Details
Title: WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.
Authors: Nirschl CJ; Werewolf Therapeutics Inc., Watertown, Massachusetts., Subramanian KK; Werewolf Therapeutics Inc., Watertown, Massachusetts., Brodkin HR; Werewolf Therapeutics Inc., Watertown, Massachusetts., Domonkos C; Werewolf Therapeutics Inc., Watertown, Massachusetts., Dwyer CJ; Werewolf Therapeutics Inc., Watertown, Massachusetts., Hicklin DJ; Werewolf Therapeutics Inc., Watertown, Massachusetts., Isaacs R; Werewolf Therapeutics Inc., Watertown, Massachusetts., Ismail NS; Werewolf Therapeutics Inc., Watertown, Massachusetts., LePrevost J; Werewolf Therapeutics Inc., Watertown, Massachusetts., Lewis Y; Werewolf Therapeutics Inc., Watertown, Massachusetts., Morris K; Werewolf Therapeutics Inc., Watertown, Massachusetts., Seidel-Dugan C; Werewolf Therapeutics Inc., Watertown, Massachusetts., Steuert Z; Werewolf Therapeutics Inc., Watertown, Massachusetts., Sullivan JM; Werewolf Therapeutics Inc., Watertown, Massachusetts., Chopra SS; Werewolf Therapeutics Inc., Watertown, Massachusetts., Salmeron A; Werewolf Therapeutics Inc., Watertown, Massachusetts., Winston WM; Werewolf Therapeutics Inc., Watertown, Massachusetts.
Source: Cancer immunology research [Cancer Immunol Res] 2026 Mar 04; Vol. 14 (3), pp. 434-449.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2326-6074
DOI:10.1158/2326-6066.CIR-25-0558