Melatonin Mitigates Central Sensitization and Nociplastic Pain in Spinal Cord and Dorsal Root Ganglia of FM Rat Model: Modulation of SIRT1/PGC-1α/MAPK/NF-κB Signaling.
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| Title: | Melatonin Mitigates Central Sensitization and Nociplastic Pain in Spinal Cord and Dorsal Root Ganglia of FM Rat Model: Modulation of SIRT1/PGC-1α/MAPK/NF-κB Signaling. |
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| Authors: | Osama J; Postgraduate program in Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt.; Department of Pharmacology & Toxicology, Misr University for Science and Technology, Giza, Egypt., El-Gazar AA; Department of Pharmacology & Toxicology, October 6 University, Giza, Egypt., Ragab GM; Department of Pharmacology & Toxicology, Misr University for Science and Technology, Giza, Egypt., El-Sayed NS; Postgraduate program in Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt.; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt., Kamel AS; Postgraduate program in Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt. Ahmed.seifeldin@pharma.cu.edu.eg.; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Giza, Egypt. Ahmed.seifeldin@pharma.cu.edu.eg. |
| Source: | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2026 Feb 13; Vol. 21 (1), pp. 12. Date of Electronic Publication: 2026 Feb 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1557-1904 |
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| DOI: | 10.1007/s11481-025-10274-7 |
