Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.
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| Title: | Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development. |
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| Authors: | Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA., Roark RS; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Connell AJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Hogarty MP; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wagh K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Wang S; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Marchitto L; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Skelly AN; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Carey JW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sowers KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ayyanathan K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Plante SJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Agostino CJ; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA., Singh A; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Martella CL; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lewis E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Rando JM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chohan N; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lora J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ding W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Campion MS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Li Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Liang B; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chowdhury RR; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Van Itallie E; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Sheng Z; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Ghosh AR; Departments of Microbiology and Immunology, Harvard Medical School, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bar KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Williams WB; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Edwards RJ; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Cain DW; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Lewis MG; Bioqual Inc., Rockville, MD 20850, USA., Batista FD; Departments of Microbiology and Immunology, Harvard Medical School, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Burton DR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kulp DW; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Korber B; New Mexico Consortium, Los Alamos, NM 87545, USA., Shapiro L; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Kwong PD; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
| Source: | Science immunology [Sci Immunol] 2026 Feb 13; Vol. 11 (116), pp. eadz3933. Date of Electronic Publication: 2026 Feb 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adz3933 |
