Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization.
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| Title: | Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization. |
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| Authors: | Ghosh AR; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA., Mishra N; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Roark RS; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Akauliya M; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Albowaidey AA; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Allen JD; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Avillion G; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Bottermann M; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Liang B; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chaudhary N; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Callaghan S; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Dye J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ellis-Pugh JR; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Roy Chowdhury R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., James NE; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Liu X; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Maiorino L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA., Villavicencio PM; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Nedellec R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Oberoi P; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sowers KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Prum T; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Rodriguez L; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA., Ssozi M; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Torres JL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Walsh AA; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Warner JE; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Weldon SR; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Xu L; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Nair U; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Burton DR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA., Shapiro L; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Kwong PD; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Irvine DJ; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA.; Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Batista FD; Batista Lab, Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. |
| Source: | Science immunology [Sci Immunol] 2026 Feb 13; Vol. 11 (116), pp. eadz5064. Date of Electronic Publication: 2026 Feb 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adz5064 |
