A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.

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Title: A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.
Authors: Alam S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Dermentzaki G; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA.; Neuroinflammation and Precision Neurology, Sanofi, Cambridge, MA, USA., Cabrera-Garcia D; Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Synapse and Network Development, Netherlands Institute for Neuroscience, Amsterdam, Netherlands., Li M; Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA., Wang R; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Campbell M; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurosciences, University of California, San Diego, CA, USA., Balbo I; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, NY, USA., Phillips BL; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Li M; Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, China., Estrada J; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Zazhytska M; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Mortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, USA., Yeh YT; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Min L; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA., Rafikian E; Mouse Neurobehavioral Core Facility, Columbia University Irving Medical Center, New York, NY, USA., Valenzuela E; Department of Biological Sciences, Columbia University, New York, NY, USA., Joseph B; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Patel T; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neuroscience, Columbia University, New York, NY, USA.; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Ustianenko D; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA.; Flagship Pioneering, Cambridge, MA, USA., Lovett H; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Feng H; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, China., Wang X; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA., Brenner-Morton S; Mortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, USA., Lin CS; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Waites CL; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neuroscience, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Wichterle H; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neuroscience, Columbia University, New York, NY, USA., Chen L; Barshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, UTHSCSA, San Antonio, TX, USA., Yang M; Mouse Neurobehavioral Core Facility, Columbia University Irving Medical Center, New York, NY, USA., Au E; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Translational Neuroscience Initiative Scholar, New York, NY, USA., Jovanovic M; Department of Biological Sciences, Columbia University, New York, NY, USA., Lomvardas S; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.; Mortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, USA., Jenkins PM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA., Yang R; Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, China., Kuo SH; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, NY, USA., Peng Y; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. yp2249@cumc.columbia.edu.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. yp2249@cumc.columbia.edu., Yang G; Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA. gy2268@cumc.columbia.edu., Harrison NL; Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA. nh2298@cumc.columbia.edu.; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, USA. nh2298@cumc.columbia.edu., Zhang C; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. cz2294@columbia.edu.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. cz2294@columbia.edu.; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, NY, USA. cz2294@columbia.edu.
Source: Nature communications [Nat Commun] 2026 Feb 13; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-69486-x