Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer.

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Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer.
Authors: Choi SP; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Yang J; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Park IB; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Kang SJ; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Park SW; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Lee CH; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Lee HJ; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Bae J; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Choi CY; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201, USA., Shin J; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Kim JI; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Jin HY; Department of Urology, School of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Lee YS; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea., Chun T; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: tchun@korea.ac.kr.
Source: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2026 Mar; Vol. 289, pp. 27-39. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Choi+SP%22">Choi SP</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+IB%22">Park IB</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+SJ%22">Kang SJ</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+SW%22">Park SW</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+CH%22">Lee CH</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bae+J%22">Bae J</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+CY%22">Choi CY</searchLink>; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201, USA.<br /><searchLink fieldCode="AU" term="%22Shin+J%22">Shin J</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JI%22">Kim JI</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jin+HY%22">Jin HY</searchLink>; Department of Urology, School of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chun+T%22">Chun T</searchLink>; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: tchun@korea.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%22101280339%22">Translational research : the journal of laboratory and clinical medicine</searchLink> [Transl Res] 2026 Mar; Vol. 289, pp. 27-39. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101280339 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-1810 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218781810%22">18781810 </searchLink><i>NLM ISO Abbreviation: </i>Transl Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.trsl.2026.02.006
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              Text: 2026 Mar
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