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Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines.

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Title: Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines.
Authors: Ravi Shankar AL; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai- Fuchs-22 Strasse-1, 30625, Hannover, Germany. abishek.laxmanan.ravi.shankar@item-extern.fraunhofer.de., Irwan J; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai- Fuchs-22 Strasse-1, 30625, Hannover, Germany., Spaenig M; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai- Fuchs-22 Strasse-1, 30625, Hannover, Germany., Carlier M; Amsterdam Institute for Life and Environment, Section Environment and Health, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands., Hansen T; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai- Fuchs-22 Strasse-1, 30625, Hannover, Germany., Zumbülte N; TZW: DVGW-Technologiezentrum Wasser (German Water Centre), Karlsruher Straße 84, 76139, Karlsruhe, Germany., Islam B; Certara Predictive Technologies, Sheffield, United Kingdom., Lundquist P; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Svensson R; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Gouin T; TG Environmental Research, Sharnbrook, United Kingdom., Hamers T; Amsterdam Institute for Life and Environment, Section Environment and Health, Vrije Universiteit Amsterdam, 1081 HV, Amsterdam, The Netherlands., Escher SE; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai- Fuchs-22 Strasse-1, 30625, Hannover, Germany.
Source: Archives of toxicology [Arch Toxicol] 2026 May; Vol. 100 (5), pp. 1877-1901. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-025-04268-w