Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease.

Saved in:
Bibliographic Details
Title: Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease.
Authors: Spencer PN; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Brown ME; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Smith EP; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA., Wang J; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Kim W; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Spiga L; Department of Pathology, Microbiology and Immunology and.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Tasneem N; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Simmons AJ; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Kim T; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Yang Y; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Xu Y; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Zheng L; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Ro J; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Kaur H; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Kang SW; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Helou MD; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Lee MA; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Arceneaux D; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Mueller KD; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA., Kuddar OS; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA., Harned MH; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Li J; Department of Pathology, Microbiology and Immunology and., Banerjee A; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA., Markham NO; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wilson KT; Department of Pathology, Microbiology and Immunology and.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Coburn LA; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Goettel JA; Department of Pathology, Microbiology and Immunology and.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Liu Q; Department of Biostatistics and Center for Quantitative Sciences, and., Washington MK; Department of Pathology, Microbiology and Immunology and.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Valdivia RH; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA., Zhu W; Department of Pathology, Microbiology and Immunology and.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Lau KS; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Feb 17; Vol. 136 (7). Date of Electronic Publication: 2026 Feb 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1558-8238
DOI:10.1172/JCI201729