The effect of prenatal balanced energy and protein supplementation on small vulnerable newborn types in low- and middle-income countries: A systematic review and meta-analysis of individual participant data.

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Title: The effect of prenatal balanced energy and protein supplementation on small vulnerable newborn types in low- and middle-income countries: A systematic review and meta-analysis of individual participant data.
Authors: Wang D; Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, Virginia, United States of America., Partap U; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America., Liu E; Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, United States of America.; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Costa JC; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America., Cliffer IR; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America., Wang M; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Nookala SK; Cytel Inc., India, on behalf of the Gates Foundation, Seattle, Washington, United States of America., Subramoney V; DVPL Tech, Dubai, United Arab Emirates., Briggs B; Certara USA, Inc., on behalf of the Gates Foundation, Seattle, Washington, United States of America., Ahmed I; Aga Khan University, Karachi, Pakistan., Argaw A; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Ariff S; Aga Khan University, Karachi, Pakistan., Bhandari N; Society for Applied Studies, New Delhi, India., Chowdhury R; Society for Applied Studies, New Delhi, India., Dailey-Chwalibóg T; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.; Agence de Formation de Recherche et d'Expertise en Santé pour l'Afrique (AFRICSanté), Bobo-Dioulasso, Burkina Faso., Hanley-Cook GT; Food and Nutrition Division, Food and Agriculture Organization of the United Nations (FAO), Rome, Italy., Huybregts L; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.; Nutrition, Diets, and Health Unit, International Food Policy Research Institute, Washington, District of Columbia, United States of America., Jehan F; Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan., Krebs NF; University of Colorado School of Medicine, Aurora, Colorado, United States of America., Lachat C; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Manandhar DS; Mother and Infant Research Activities (MIRA), Kathmandu, Nepal., McClure EM; RTI International, Durham, North Carolina, United States of America., Moore SE; Department of Women & Children's Health, King's College London, London, United Kingdom.; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Muhammad A; VITAL Pakistan Trust, Karachi, Pakistan., Nisar MI; Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan., Prentice AM; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Roberfroid D; Faculty of Medicine, University of Namur, Namur, Belgium.; Belgian Health Care Knowledge Centre, Brussels, Belgium., Saville NM; Institute for Global Health, University College London, London, United Kingdom., Shafiq Y; Center of Excellence for Trauma and Emergencies and Community Health Sciences, The Aga Khan University, Karachi, Pakistan.; Global Advancement of Infants and Mothers (AIM), Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Harvard Humanitarian Initiative, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America., Shrestha BP; Mother and Infant Research Activities (MIRA), Kathmandu, Nepal., Sonko B; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Soofi S; Aga Khan University, Karachi, Pakistan., Taneja S; Society for Applied Studies, New Delhi, India., Toe LC; Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.; Nutrition and Metabolic Diseases Unit, Health Sciences Research Institute (IRSS), Bobo-Dioulasso, Burkina Faso., Fawzi WW; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America.
Source: PLoS medicine [PLoS Med] 2026 Feb 17; Vol. 23 (2), pp. e1004716. Date of Electronic Publication: 2026 Feb 17 (Print Publication: 2026).
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet ISSN: 1549-1676 (Electronic) Linking ISSN: 15491277 NLM ISO Abbreviation: PLoS Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1549-1676
DOI:10.1371/journal.pmed.1004716